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KMID : 0857020140290010063
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Kosin Medical Journal
2014 Volume.29 No. 1 p.63 ~ p.68
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A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman
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Shin Young-Shin
Sim Eun-Hee
Yeo Chang-Woo
Kang Jin-Du
Kim Ji-Yeon
Park Seun-Ja
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Abstract
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Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.
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KEYWORD
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Isoniazid, Metabolic acidosis, Pyridoxine, Seizure
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